Assay Detail
Functional
CHEMBL978069
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Cytotoxicity against human KYSE70 cells after 96 hrs by microtiter assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KYSE-70 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationships of novel heteroaryl-acrylonitriles as cytotoxic and antibacterial agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.41 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL486866 | — | — | 1 | 7.30 |
| CHEMBL440896 | — | — | 1 | 6.72 |
| CHEMBL452338 | — | — | 1 | 6.42 |
| CHEMBL510628 | — | — | 1 | 6.29 |
| CHEMBL509447 | — | — | 1 | 5.88 |
| CHEMBL454676 | — | — | 1 | 5.62 |
| CHEMBL508642 | — | — | 1 | 5.58 |
| CHEMBL503790 | — | — | 1 | 5.54 |
| CHEMBL451824 | — | — | 1 | 5.39 |
| CHEMBL452328 | — | — | 1 | 5.37 |
| CHEMBL507487 | — | — | 1 | 5.28 |
| CHEMBL671 | THIOTEPA | 4.0 | 1 | 5.27 |
| CHEMBL454418 | — | — | 1 | 5.25 |
| CHEMBL447255 | — | — | 1 | 5.17 |
| CHEMBL455399 | — | — | 1 | 5.14 |
| CHEMBL505911 | — | — | 1 | 5.09 |
| CHEMBL519890 | — | — | 1 | 4.91 |
| CHEMBL486867 | — | — | 1 | 4.79 |
| CHEMBL852 | MELPHALAN | 4.0 | 1 | 4.79 |
| CHEMBL572 | NITROFURANTOIN | 4.0 | 1 | 4.64 |
| CHEMBL452337 | — | — | 1 | 4.43 |
| CHEMBL454419 | — | — | 1 | 4.24 |
| CHEMBL455419 | — | — | 1 | - |
| CHEMBL509840 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL486866 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL440896 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL452338 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL510628 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL509447 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL454676 | — | IC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL508642 | — | IC50 | = | 2630.0 | nM | 5.58 |
| CHEMBL503790 | — | IC50 | = | 2910.0 | nM | 5.54 |
| CHEMBL451824 | — | IC50 | = | 4060.0 | nM | 5.39 |
| CHEMBL452328 | — | IC50 | = | 4250.0 | nM | 5.37 |
| CHEMBL507487 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL671 | THIOTEPA | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL454418 | — | IC50 | = | 5570.0 | nM | 5.25 |
| CHEMBL447255 | — | IC50 | = | 6820.0 | nM | 5.17 |
| CHEMBL455399 | — | IC50 | = | 7280.0 | nM | 5.14 |
| CHEMBL505911 | — | IC50 | = | 8140.0 | nM | 5.09 |
| CHEMBL519890 | — | IC50 | = | 12180.0 | nM | 4.91 |
| CHEMBL486867 | — | IC50 | = | 16040.0 | nM | 4.79 |
| CHEMBL852 | MELPHALAN | IC50 | = | 16160.0 | nM | 4.79 |
| CHEMBL572 | NITROFURANTOIN | IC50 | = | 22800.0 | nM | 4.64 |
| CHEMBL452337 | — | IC50 | = | 37150.0 | nM | 4.43 |
| CHEMBL454419 | — | IC50 | = | 57400.0 | nM | 4.24 |
| CHEMBL455419 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL509840 | — | IC50 | - | — | - |