Assay Detail
Functional
CHEMBL978075
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Cytotoxicity against human LCLC-103H cells after 96 hrs by microtiter assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LCLC-103H |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationships of novel heteroaryl-acrylonitriles as cytotoxic and antibacterial agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.64 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL486866 | — | — | 1 | 7.52 |
| CHEMBL452338 | — | — | 1 | 6.96 |
| CHEMBL440896 | — | — | 1 | 6.68 |
| CHEMBL509447 | — | — | 1 | 6.39 |
| CHEMBL510628 | — | — | 1 | 6.06 |
| CHEMBL503790 | — | — | 1 | 5.88 |
| CHEMBL454676 | — | — | 1 | 5.83 |
| CHEMBL508642 | — | — | 1 | 5.77 |
| CHEMBL454418 | — | — | 1 | 5.75 |
| CHEMBL452328 | — | — | 1 | 5.71 |
| CHEMBL572 | NITROFURANTOIN | 4.0 | 1 | 5.63 |
| CHEMBL451824 | — | — | 1 | 5.46 |
| CHEMBL486867 | — | — | 1 | 5.43 |
| CHEMBL852 | MELPHALAN | 4.0 | 1 | 5.40 |
| CHEMBL519890 | — | — | 1 | 5.28 |
| CHEMBL671 | THIOTEPA | 4.0 | 1 | 5.16 |
| CHEMBL447255 | — | — | 1 | 5.13 |
| CHEMBL505911 | — | — | 1 | 5.13 |
| CHEMBL454419 | — | — | 1 | 5.13 |
| CHEMBL455399 | — | — | 1 | 5.11 |
| CHEMBL507487 | — | — | 1 | 4.92 |
| CHEMBL452337 | — | — | 1 | 4.71 |
| CHEMBL455419 | — | — | 1 | 4.64 |
| CHEMBL509840 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL486866 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL452338 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL440896 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL509447 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL510628 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL503790 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL454676 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL508642 | — | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL454418 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL452328 | — | IC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL572 | NITROFURANTOIN | IC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL451824 | — | IC50 | = | 3480.0 | nM | 5.46 |
| CHEMBL486867 | — | IC50 | = | 3750.0 | nM | 5.43 |
| CHEMBL852 | MELPHALAN | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL519890 | — | IC50 | = | 5240.0 | nM | 5.28 |
| CHEMBL671 | THIOTEPA | IC50 | = | 6970.0 | nM | 5.16 |
| CHEMBL447255 | — | IC50 | = | 7420.0 | nM | 5.13 |
| CHEMBL505911 | — | IC50 | = | 7370.0 | nM | 5.13 |
| CHEMBL454419 | — | IC50 | = | 7460.0 | nM | 5.13 |
| CHEMBL455399 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL507487 | — | IC50 | = | 12060.0 | nM | 4.92 |
| CHEMBL452337 | — | IC50 | = | 19660.0 | nM | 4.71 |
| CHEMBL455419 | — | IC50 | = | 22760.0 | nM | 4.64 |
| CHEMBL509840 | — | IC50 | > | 20000.0 | nM | - |