Assay Detail
Binding
CHEMBL978153
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Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells by scintillation counting
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
N-Benzyl-N-(pyrrolidin-3-yl)carboxamides as a new class of selective dual serotonin/noradrenaline reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.49 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL477374 | — | — | 1 | 8.30 |
| CHEMBL450813 | — | — | 1 | 8.30 |
| CHEMBL247733 | — | — | 1 | 8.05 |
| CHEMBL476954 | — | — | 1 | 7.92 |
| CHEMBL513139 | — | — | 1 | 7.89 |
| CHEMBL448900 | — | — | 1 | 7.77 |
| CHEMBL477584 | — | — | 1 | 7.62 |
| CHEMBL512967 | — | — | 1 | 7.60 |
| CHEMBL446281 | — | — | 1 | 7.58 |
| CHEMBL469068 | — | — | 1 | 7.57 |
| CHEMBL513313 | — | — | 1 | 7.48 |
| CHEMBL512472 | — | — | 1 | 7.42 |
| CHEMBL513360 | — | — | 1 | 7.39 |
| CHEMBL449145 | — | — | 1 | 7.39 |
| CHEMBL477580 | — | — | 1 | 7.36 |
| CHEMBL466963 | — | — | 1 | 7.14 |
| CHEMBL517963 | — | — | 1 | 7.04 |
| CHEMBL469222 | — | — | 1 | 7.03 |
| CHEMBL513884 | — | — | 1 | 6.91 |
| CHEMBL518580 | — | — | 1 | 6.79 |
| CHEMBL469233 | — | — | 1 | 6.71 |
| CHEMBL477586 | — | — | 1 | - |
| CHEMBL476116 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL477374 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL450813 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL247733 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL476954 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL513139 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL448900 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL477584 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL512967 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL446281 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL469068 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL513313 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL512472 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL513360 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL449145 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL477580 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL466963 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL517963 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL469222 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL513884 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL518580 | — | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL469233 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL477586 | — | IC50 | > | 400.0 | nM | - |
| CHEMBL476116 | — | IC50 | > | 400.0 | nM | - |