Assay Detail
Binding
CHEMBL978815
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]beta-CIT from human SERT in human platelet plasma membrane
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Ibogaine, a noncompetitive inhibitor of serotonin transport, acts by stabilizing the cytoplasm-facing state of the transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Bmax | 1 | - | - |
| Kd | 1 | 9.06 | 9.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL215376 | — | — | 2 | 9.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL215376 | — | Kd | = | 0.88 | nM | 9.06 |
| CHEMBL215376 | — | Bmax | = | 1.3 | pmol/mg | - |