Assay Detail
Binding
CHEMBL980603
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Displacement of [3H]MDL100907 from 5HT2A receptor in Sprague-Dawley rat brain by liquid scintillation spectroscopy
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The role of lipophilicity in determining binding affinity and functional activity for 5-HT2A receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.64 | 9.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL149024 | — | — | 1 | 9.64 |
| CHEMBL101008 | — | — | 1 | 7.83 |
| CHEMBL267777 | RITANSERIN | 2.0 | 1 | 7.44 |
| CHEMBL465525 | — | — | 1 | 6.50 |
| CHEMBL65547 | PSILOCIN | 2.0 | 1 | 6.49 |
| CHEMBL445687 | — | — | 1 | 6.32 |
| CHEMBL12420 | N,N-DIMETHYLTRYPTAMINE | 2.0 | 1 | 5.79 |
| CHEMBL509461 | — | — | 1 | 5.60 |
| CHEMBL13086 | — | — | 1 | 5.43 |
| CHEMBL13147 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL149024 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL101008 | — | Ki | = | 14.8 | nM | 7.83 |
| CHEMBL267777 | RITANSERIN | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL465525 | — | Ki | = | 313.0 | nM | 6.50 |
| CHEMBL65547 | PSILOCIN | Ki | = | 323.0 | nM | 6.49 |
| CHEMBL445687 | — | Ki | = | 476.0 | nM | 6.32 |
| CHEMBL12420 | N,N-DIMETHYLTRYPTAMINE | Ki | = | 1636.0 | nM | 5.79 |
| CHEMBL509461 | — | Ki | = | 2505.0 | nM | 5.60 |
| CHEMBL13086 | — | Ki | = | 3676.0 | nM | 5.43 |
| CHEMBL13147 | — | Ki | = | 4611.0 | nM | 5.34 |