Assay Detail
Binding
CHEMBL980843
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Inhibition of bovine mitochondrial MAOA
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, molecular modeling studies and selective inhibitory activity against MAO of N1-propanoyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 5.51 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL472716 | — | — | 1 | 6.70 |
| CHEMBL514297 | — | — | 1 | 6.70 |
| CHEMBL18116 | TOLOXATONE | 4.0 | 1 | 6.42 |
| CHEMBL515389 | — | — | 1 | 6.30 |
| CHEMBL514151 | — | — | 1 | 6.12 |
| CHEMBL474940 | — | — | 1 | 6.09 |
| CHEMBL489085 | — | — | 1 | 6.08 |
| CHEMBL474939 | — | — | 1 | 6.07 |
| CHEMBL505492 | — | — | 1 | 6.00 |
| CHEMBL447022 | — | — | 1 | 6.00 |
| CHEMBL472918 | — | — | 1 | 6.00 |
| CHEMBL515250 | — | — | 1 | 6.00 |
| CHEMBL523765 | — | — | 1 | 5.93 |
| CHEMBL474738 | — | — | 1 | 5.92 |
| CHEMBL514139 | — | — | 1 | 5.92 |
| CHEMBL508959 | — | — | 1 | 5.85 |
| CHEMBL472903 | — | — | 1 | 5.25 |
| CHEMBL489086 | — | — | 1 | 5.14 |
| CHEMBL515237 | — | — | 1 | 5.14 |
| CHEMBL472902 | — | — | 1 | 5.00 |
| CHEMBL472904 | — | — | 1 | 5.00 |
| CHEMBL86304 | MOCLOBEMIDE | 4.0 | 1 | 4.94 |
| CHEMBL472713 | — | — | 1 | 4.71 |
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 4.42 |
| CHEMBL489084 | — | — | 1 | 4.20 |
| CHEMBL473309 | — | — | 1 | 4.13 |
| CHEMBL472712 | — | — | 1 | 4.12 |
| CHEMBL508175 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL472716 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL514297 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL18116 | TOLOXATONE | IC50 | = | 380.19 | nM | 6.42 |
| CHEMBL515389 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL514151 | — | IC50 | = | 758.58 | nM | 6.12 |
| CHEMBL474940 | — | IC50 | = | 812.83 | nM | 6.09 |
| CHEMBL489085 | — | IC50 | = | 831.76 | nM | 6.08 |
| CHEMBL474939 | — | IC50 | = | 851.14 | nM | 6.07 |
| CHEMBL505492 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL447022 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL472918 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL515250 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL523765 | — | IC50 | = | 1174.9 | nM | 5.93 |
| CHEMBL474738 | — | IC50 | = | 1202.26 | nM | 5.92 |
| CHEMBL514139 | — | IC50 | = | 1202.26 | nM | 5.92 |
| CHEMBL508959 | — | IC50 | = | 1412.54 | nM | 5.85 |
| CHEMBL472903 | — | IC50 | = | 5623.41 | nM | 5.25 |
| CHEMBL489086 | — | IC50 | = | 7244.36 | nM | 5.14 |
| CHEMBL515237 | — | IC50 | = | 7244.36 | nM | 5.14 |
| CHEMBL472902 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL472904 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL86304 | MOCLOBEMIDE | IC50 | = | 11481.54 | nM | 4.94 |
| CHEMBL472713 | — | IC50 | = | 19498.45 | nM | 4.71 |
| CHEMBL972 | SELEGILINE | IC50 | = | 38018.94 | nM | 4.42 |
| CHEMBL489084 | — | IC50 | = | 63095.73 | nM | 4.20 |
| CHEMBL473309 | — | IC50 | = | 74131.02 | nM | 4.13 |
| CHEMBL472712 | — | IC50 | = | 75857.76 | nM | 4.12 |
| CHEMBL508175 | — | IC50 | = | 100000.0 | nM | 4.00 |