Assay Detail
Binding
CHEMBL981171
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Inhibition of equine BChE by Ellman's method
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.01 | 6.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL478193 | — | — | 1 | 6.15 |
| CHEMBL477141 | — | — | 1 | 6.15 |
| CHEMBL477140 | — | — | 1 | 6.14 |
| CHEMBL514534 | — | — | 1 | 5.97 |
| CHEMBL478194 | — | — | 1 | 5.63 |
| CHEMBL476119 | — | — | 1 | - |
| CHEMBL516265 | — | — | 1 | - |
| CHEMBL478817 | — | — | 1 | - |
| CHEMBL478605 | — | — | 1 | - |
| CHEMBL478607 | — | — | 1 | - |
| CHEMBL478638 | — | — | 1 | - |
| CHEMBL514870 | — | — | 1 | - |
| CHEMBL478637 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL478193 | — | IC50 | = | 708.0 | nM | 6.15 |
| CHEMBL477141 | — | IC50 | = | 715.0 | nM | 6.15 |
| CHEMBL477140 | — | IC50 | = | 718.0 | nM | 6.14 |
| CHEMBL514534 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL478194 | — | IC50 | = | 2344.0 | nM | 5.63 |
| CHEMBL476119 | — | IC50 | - | — | - | |
| CHEMBL516265 | — | IC50 | - | — | - | |
| CHEMBL478817 | — | IC50 | - | — | - | |
| CHEMBL478605 | — | IC50 | - | — | - | |
| CHEMBL478607 | — | IC50 | - | — | - | |
| CHEMBL478638 | — | IC50 | - | — | - | |
| CHEMBL514870 | — | IC50 | - | — | - | |
| CHEMBL478637 | — | IC50 | - | — | - |