Assay Detail
Functional
CHEMBL981350
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Antiproliferative activity against mouse P388 cells after 48 hrs by MTT assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | P388 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A mammalian cell agar-diffusion assay for the detection of toxic compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.29 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1554 | DACTINOMYCIN | 4.0 | 1 | 9.70 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 9.15 |
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 8.92 |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 8.23 |
| CHEMBL50588 | EMETINE | 4.0 | 1 | 8.15 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.62 |
| CHEMBL178 | DAUNORUBICIN | 4.0 | 1 | 7.55 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.18 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.13 |
| CHEMBL1237054 | PLICAMYCIN | 4.0 | 1 | 6.96 |
| CHEMBL43 | AMSACRINE | 4.0 | 1 | 6.64 |
| CHEMBL727 | THIOGUANINE | 4.0 | 1 | 6.52 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 6.21 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 5.91 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 5.52 |
| CHEMBL1489 | AZACITIDINE | 4.0 | 1 | 5.30 |
| CHEMBL2021450 | CRASSIN ACETATE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1554 | DACTINOMYCIN | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL90555 | VINCRISTINE | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL61 | PODOFILOX | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL50588 | EMETINE | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL107 | COLCHICINE | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL178 | DAUNORUBICIN | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL1237054 | PLICAMYCIN | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL43 | AMSACRINE | IC50 | = | 229.0 | nM | 6.64 |
| CHEMBL727 | THIOGUANINE | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 609.0 | nM | 6.21 |
| CHEMBL803 | CYTARABINE | IC50 | = | 1233.0 | nM | 5.91 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1489 | AZACITIDINE | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2021450 | CRASSIN ACETATE | IC50 | = | 1.0 | ug.mL-1 | - |