Assay Detail
Binding
CHEMBL981909
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Binding affinity at human EphB2 receptor by isothermal titration calorimetry
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Three-dimensional structure of the EphB2 receptor in complex with an antagonistic peptide reveals a novel mode of inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 11 | 5.23 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL526325 | — | — | 1 | 5.52 |
| CHEMBL448652 | — | — | 1 | 5.22 |
| CHEMBL508644 | — | — | 1 | 5.22 |
| CHEMBL526907 | — | — | 1 | 4.96 |
| CHEMBL508295 | — | — | 1 | - |
| CHEMBL504627 | — | — | 1 | - |
| CHEMBL505364 | — | — | 1 | - |
| CHEMBL453443 | — | — | 1 | - |
| CHEMBL451203 | — | — | 1 | - |
| CHEMBL504700 | — | — | 1 | - |
| CHEMBL525059 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL526325 | — | Kd | = | 3000.0 | nM | 5.52 |
| CHEMBL448652 | — | Kd | = | 6000.0 | nM | 5.22 |
| CHEMBL508644 | — | Kd | = | 6000.0 | nM | 5.22 |
| CHEMBL526907 | — | Kd | = | 11000.0 | nM | 4.96 |
| CHEMBL508295 | — | Kd | > | 50000.0 | nM | - |
| CHEMBL504627 | — | Kd | > | 50000.0 | nM | - |
| CHEMBL505364 | — | Kd | > | 50000.0 | nM | - |
| CHEMBL453443 | — | Kd | > | 50000.0 | nM | - |
| CHEMBL451203 | — | Kd | > | 50000.0 | nM | - |
| CHEMBL504700 | — | Kd | > | 50000.0 | nM | - |
| CHEMBL525059 | — | Kd | > | 50000.0 | nM | - |