Compound Detail
CHEMBL526325
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CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)O
Basic Information
| ChEMBL ID | CHEMBL526325 |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | GETSFTABZTXYQF-VDZJBNKISA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
1489.7
MW (Da)
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 1 meas. best 5.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Ephrin type-B receptor 2 CHEMBL3290 | Kd | 5.52 | 5.52 | 3000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Ephrin type-B receptor 2 | Kd | = | 3000.0 | nM | 5.52 | Binding affinity at human EphB2 receptor by isothermal titration calorimetry | 17897949 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17897949 | 10.1074/jbc.m706340200 | Ephrin type-B receptor 2 | 1 |
Data from ChEMBL 36 via Core Engine