Assay Detail
Functional
CHEMBL982658
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Inhibition of PHA-induced IL2 production in human Jurkat T lymphocytes
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel potent and selective Ca2+ release-activated Ca2+ (CRAC) channel inhibitors. Part 3: synthesis and CRAC channel inhibitory activity of 4'-[(trifluoromethyl)pyrazol-1-yl]carboxanilides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.56 | 8.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL485208 | — | — | 1 | 8.23 |
| CHEMBL484354 | — | — | 1 | 7.82 |
| CHEMBL431431 | — | — | 1 | 7.80 |
| CHEMBL262766 | — | — | 1 | 7.77 |
| CHEMBL459002 | — | — | 1 | 7.75 |
| CHEMBL483198 | — | — | 1 | 7.75 |
| CHEMBL520993 | — | — | 1 | 7.75 |
| CHEMBL456852 | — | — | 1 | 7.62 |
| CHEMBL485411 | — | — | 1 | 7.48 |
| CHEMBL456851 | — | — | 1 | 7.47 |
| CHEMBL456853 | — | — | 1 | 7.03 |
| CHEMBL521340 | — | — | 1 | 7.03 |
| CHEMBL514728 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL485208 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL484354 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL431431 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL262766 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL459002 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL483198 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL520993 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL456852 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL485411 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL456851 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL456853 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL521340 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL514728 | — | IC50 | = | 160.0 | nM | 6.80 |