Assay Detail
Binding
CHEMBL982895
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Displacement of [3H]spiperone from dopamine D2 receptor in CRL:CD(SD)BR-COBS rat brain striatum
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of new arylpiperazinylalkylthiobenzimidazole, benzothiazole, or benzoxazole derivatives as potent and selective 5-HT1A serotonin receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.94 | 7.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL477200 | — | — | 1 | 7.59 |
| CHEMBL514074 | — | — | 1 | 7.43 |
| CHEMBL476722 | — | — | 1 | 7.33 |
| CHEMBL477765 | — | — | 1 | 7.23 |
| CHEMBL517962 | — | — | 1 | 6.37 |
| CHEMBL478413 | — | — | 1 | 6.33 |
| CHEMBL479026 | — | — | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL477200 | — | Ki | = | 25.8 | nM | 7.59 |
| CHEMBL514074 | — | Ki | = | 37.3 | nM | 7.43 |
| CHEMBL476722 | — | Ki | = | 46.6 | nM | 7.33 |
| CHEMBL477765 | — | Ki | = | 58.3 | nM | 7.23 |
| CHEMBL517962 | — | Ki | = | 429.0 | nM | 6.37 |
| CHEMBL478413 | — | Ki | = | 462.0 | nM | 6.33 |
| CHEMBL479026 | — | Ki | = | 532.0 | nM | 6.27 |