Assay Detail
Binding
CHEMBL982896
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]ketanserin from 5HT2A receptor in CRL:CD(SD)BR-COBS rat brain cortex
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of new arylpiperazinylalkylthiobenzimidazole, benzothiazole, or benzoxazole derivatives as potent and selective 5-HT1A serotonin receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.83 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL478413 | — | — | 1 | 7.10 |
| CHEMBL477200 | — | — | 1 | 7.02 |
| CHEMBL477765 | — | — | 1 | 6.97 |
| CHEMBL517962 | — | — | 1 | 6.76 |
| CHEMBL479026 | — | — | 1 | 6.74 |
| CHEMBL476722 | — | — | 1 | 6.68 |
| CHEMBL514074 | — | — | 1 | 6.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL478413 | — | Ki | = | 78.8 | nM | 7.10 |
| CHEMBL477200 | — | Ki | = | 96.1 | nM | 7.02 |
| CHEMBL477765 | — | Ki | = | 106.0 | nM | 6.97 |
| CHEMBL517962 | — | Ki | = | 174.0 | nM | 6.76 |
| CHEMBL479026 | — | Ki | = | 183.0 | nM | 6.74 |
| CHEMBL476722 | — | Ki | = | 207.0 | nM | 6.68 |
| CHEMBL514074 | — | Ki | = | 298.0 | nM | 6.53 |