Assay Detail
Functional
CHEMBL983579
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Agonist activity at muscarinic M1 receptor
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moieties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 7.18 | 9.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL490797 | — | — | 1 | 9.12 |
| CHEMBL522451 | — | — | 1 | 9.07 |
| CHEMBL489576 | — | — | 1 | 8.98 |
| CHEMBL490598 | — | — | 1 | 8.97 |
| CHEMBL521914 | — | — | 1 | 8.77 |
| CHEMBL491209 | — | — | 1 | 8.68 |
| CHEMBL478034 | — | — | 1 | 6.92 |
| CHEMBL477821 | — | — | 1 | 6.58 |
| CHEMBL522460 | — | — | 1 | 6.54 |
| CHEMBL490597 | — | — | 1 | 6.45 |
| CHEMBL478662 | — | — | 1 | 6.39 |
| CHEMBL476990 | — | — | 1 | 6.31 |
| CHEMBL523657 | — | — | 1 | 5.99 |
| CHEMBL514689 | — | — | 1 | 5.96 |
| CHEMBL518747 | — | — | 1 | 5.82 |
| CHEMBL491208 | — | — | 1 | 5.80 |
| CHEMBL515489 | — | — | 1 | 5.75 |
| CHEMBL491818 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL490797 | — | EC50 | = | 0.76 | nM | 9.12 |
| CHEMBL522451 | — | EC50 | = | 0.85 | nM | 9.07 |
| CHEMBL489576 | — | EC50 | = | 1.04 | nM | 8.98 |
| CHEMBL490598 | — | EC50 | = | 1.06 | nM | 8.97 |
| CHEMBL521914 | — | EC50 | = | 1.71 | nM | 8.77 |
| CHEMBL491209 | — | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL478034 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL477821 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL522460 | — | EC50 | = | 289.0 | nM | 6.54 |
| CHEMBL490597 | — | EC50 | = | 356.0 | nM | 6.45 |
| CHEMBL478662 | — | EC50 | = | 410.0 | nM | 6.39 |
| CHEMBL476990 | — | EC50 | = | 490.0 | nM | 6.31 |
| CHEMBL523657 | — | EC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL514689 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL518747 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL491208 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL515489 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL491818 | — | EC50 | > | 10.0 | nM | - |