Assay Detail
Functional
CHEMBL983678
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Antagonist activity at progesterone receptor assessed as progesterone-induced alkaline phosphatase activity in human T47D cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T47D |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1,5-Dihydro-benzo[e][1,4]oxazepin-2(1H)-ones containing a 7-(5'-cyanopyrrol-2-yl) group as nonsteroidal progesterone receptor modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.59 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1276308 | MIFEPRISTONE | 4.0 | 1 | 9.70 |
| CHEMBL483246 | — | — | 1 | 8.18 |
| CHEMBL521610 | — | — | 1 | 8.00 |
| CHEMBL520169 | — | — | 1 | 7.95 |
| CHEMBL521760 | — | — | 1 | 7.84 |
| CHEMBL521141 | — | — | 1 | 7.84 |
| CHEMBL491030 | — | — | 1 | 7.77 |
| CHEMBL523825 | — | — | 1 | 7.44 |
| CHEMBL489991 | — | — | 1 | 7.25 |
| CHEMBL482625 | — | — | 1 | 6.92 |
| CHEMBL482624 | — | — | 1 | 6.76 |
| CHEMBL483454 | — | — | 1 | 6.71 |
| CHEMBL482831 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1276308 | MIFEPRISTONE | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL483246 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL521610 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL520169 | — | IC50 | = | 11.3 | nM | 7.95 |
| CHEMBL521760 | — | IC50 | = | 14.6 | nM | 7.84 |
| CHEMBL521141 | — | IC50 | = | 14.3 | nM | 7.84 |
| CHEMBL491030 | — | IC50 | = | 17.1 | nM | 7.77 |
| CHEMBL523825 | — | IC50 | = | 36.5 | nM | 7.44 |
| CHEMBL489991 | — | IC50 | = | 56.6 | nM | 7.25 |
| CHEMBL482625 | — | IC50 | = | 119.8 | nM | 6.92 |
| CHEMBL482624 | — | IC50 | = | 175.1 | nM | 6.76 |
| CHEMBL483454 | — | IC50 | = | 197.4 | nM | 6.71 |
| CHEMBL482831 | — | IC50 | = | 500.0 | nM | 6.30 |