Compound Detail
CHEMBL482624
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Cn1c(C#N)ccc1-c1ccc2c(c1)C(c1cccc(Cl)c1)(c1cccc(Cl)c1)OCC(=O)N2
Basic Information
| ChEMBL ID | CHEMBL482624 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UQOQTGNAPADHDP-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
488.4
MW (Da)
6.13
ALogP
4
HBA
1
HBD
67.0
PSA (Ų)
0.38
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.76
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Progesterone receptor CHEMBL208 | IC50 | 6.76 | 6.76 | 175.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Progesterone receptor | IC50 | = | 175.1 | nM | 6.76 | Antagonist activity at progesterone receptor assessed as progesterone-induced al... | 18722119 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18722119 | 10.1016/j.bmcl.2008.08.015 | Progesterone receptor | 1 |
Data from ChEMBL 36 via Core Engine