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Assay Detail

CHEMBL983826

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Inhibition of human recombinant CYP2C9 transfected in Escherichia coli co-expressed with human NADPH reductase
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cytochrome P450 2C9 (CHEMBL3397)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity.
Angell R, Aston NM, Bamborough P, Buckton JB, Cockerill S, deBoeck SJ, Edwards CD, Holmes DS, Jones KL, Laine DI, Patel S, Smee PA, Smith KJ, Somers DO, Walker AL.
Bioorg Med Chem Lett (2008) 18 : 4428 -4432
PubMed 18614366 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 5.36 5.36

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL478649 1 5.36

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL478649 IC50 = 4400.0 nM 5.36