Assay Detail
Functional
CHEMBL984133
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Inhibition of LPS-induced TNFalpha production in human THP1 cells
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and characterization of the N-phenyl-N'-naphthylurea class of p38 kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.80 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL491462 | — | — | 1 | 8.30 |
| CHEMBL505951 | — | — | 1 | 8.29 |
| CHEMBL523978 | — | — | 1 | 8.26 |
| CHEMBL381743 | — | — | 1 | 8.10 |
| CHEMBL454833 | — | — | 1 | 8.07 |
| CHEMBL518150 | — | — | 1 | 8.06 |
| CHEMBL510740 | — | — | 1 | 8.05 |
| CHEMBL451104 | — | — | 1 | 8.03 |
| CHEMBL470859 | — | — | 1 | 8.03 |
| CHEMBL451523 | — | — | 1 | 8.00 |
| CHEMBL453999 | — | — | 1 | 8.00 |
| CHEMBL453729 | — | — | 1 | 7.92 |
| CHEMBL448568 | — | — | 1 | 7.92 |
| CHEMBL504583 | — | — | 1 | 7.82 |
| CHEMBL103667 | DORAMAPIMOD | 2.0 | 1 | 7.75 |
| CHEMBL410761 | — | — | 1 | 7.54 |
| CHEMBL499149 | — | — | 1 | 7.54 |
| CHEMBL519161 | — | — | 1 | 7.12 |
| CHEMBL104749 | — | — | 1 | 6.85 |
| CHEMBL473880 | — | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL491462 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL505951 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL523978 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL381743 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL454833 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL518150 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL510740 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL451104 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL470859 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL451523 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL453999 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL453729 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL448568 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL504583 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL103667 | DORAMAPIMOD | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL410761 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL499149 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL519161 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL104749 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL473880 | — | IC50 | = | 380.0 | nM | 6.42 |