Assay Detail
Binding
CHEMBL984306
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Promotion of flag-tagged cIAP1 degradation in human HT1080 cells assessed as decrease in cIAPI production after 3 hrs
14
Total Activities
14
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HT-1080 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Baculoviral IAP repeat-containing protein 2 (CHEMBL5462) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Degradation-promoters of cellular inhibitor of apoptosis protein 1 based on bestatin and actinonin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.43 | 6.28 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL457292 | — | — | 1 | 6.28 |
| CHEMBL457092 | BESTATIN METHYL ESTER | — | 1 | 6.16 |
| CHEMBL458592 | — | — | 1 | 6.08 |
| CHEMBL457093 | — | — | 1 | 5.97 |
| CHEMBL457293 | — | — | 1 | 5.90 |
| CHEMBL457060 | — | — | 1 | 5.81 |
| CHEMBL458594 | — | — | 1 | 5.33 |
| CHEMBL458777 | — | — | 1 | 5.04 |
| CHEMBL457466 | — | — | 1 | 4.92 |
| CHEMBL457291 | — | — | 1 | 4.70 |
| CHEMBL458563 | — | — | 1 | 4.62 |
| CHEMBL458564 | — | — | 1 | 4.34 |
| CHEMBL458593 | — | — | 1 | - |
| CHEMBL458586 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL457292 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL457092 | BESTATIN METHYL ESTER | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL458592 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL457093 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL457293 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL457060 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL458594 | — | IC50 | = | 4690.0 | nM | 5.33 |
| CHEMBL458777 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL457466 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL457291 | — | IC50 | = | 19900.0 | nM | 4.70 |
| CHEMBL458563 | — | IC50 | = | 24100.0 | nM | 4.62 |
| CHEMBL458564 | — | IC50 | = | 45200.0 | nM | 4.34 |
| CHEMBL458593 | — | Activity | - | — | - | |
| CHEMBL458586 | — | IC50 | > | 20000.0 | nM | - |