Assay Detail
ADMET
CHEMBL984537
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Inhibition of CYP2C9
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Optimization and structure-activity relationship of a series of 1-phenyl-1,8-naphthyridin-4-one-3-carboxamides: identification of MK-0873, a potent and effective PDE4 inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.31 | 4.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL485629 | MK-0873 | 2.0 | 1 | 4.39 |
| CHEMBL485620 | — | — | 1 | 4.23 |
| CHEMBL372575 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL485629 | MK-0873 | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL485620 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL372575 | — | IC50 | <= | 1000.0 | nM | - |