Assay Detail
Binding
CHEMBL985924
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Inhibition of ovine COX1 by enzyme immuno assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of 1-(methanesulfonyl- and aminosulfonylphenyl)acetylenes that possess a 2-(N-difluoromethyl-1,2-dihydropyridin-2-one) pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.29 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25 | ASPIRIN | 4.0 | 1 | 6.46 |
| CHEMBL521 | IBUPROFEN | 4.0 | 1 | 5.54 |
| CHEMBL447148 | — | — | 1 | 5.28 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 5.11 |
| CHEMBL481613 | — | — | 1 | 4.85 |
| CHEMBL482206 | — | — | 1 | 4.49 |
| CHEMBL521440 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25 | ASPIRIN | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL521 | IBUPROFEN | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL447148 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL118 | CELECOXIB | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL481613 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL482206 | — | IC50 | = | 32400.0 | nM | 4.49 |
| CHEMBL521440 | — | IC50 | > | 100000.0 | nM | - |