Assay Detail
ADMET
CHEMBL986248
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Inhibition of CYP2C9
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Potent, selective and orally bioavailable dihydropyrimidine inhibitors of Rho kinase (ROCK1) as potential therapeutic agents for cardiovascular diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.62 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL519680 | — | — | 1 | 6.19 |
| CHEMBL521347 | — | — | 1 | 5.60 |
| CHEMBL485612 | — | — | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL519680 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL521347 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL485612 | — | IC50 | = | 8400.0 | nM | 5.08 |