Assay Detail
ADMET
CHEMBL986249
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP2D6
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Potent, selective and orally bioavailable dihydropyrimidine inhibitors of Rho kinase (ROCK1) as potential therapeutic agents for cardiovascular diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.90 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL519680 | — | — | 1 | 7.05 |
| CHEMBL520828 | — | — | 1 | 6.70 |
| CHEMBL483574 | — | — | 1 | 5.92 |
| CHEMBL485612 | — | — | 1 | 5.68 |
| CHEMBL483402 | — | — | 1 | 5.43 |
| CHEMBL521347 | — | — | 1 | 5.28 |
| CHEMBL483401 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL519680 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL520828 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL483574 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL485612 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL483402 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL521347 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL483401 | — | IC50 | = | 5700.0 | nM | 5.24 |