Assay Detail
Binding
CHEMBL986941
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Displacement of [3H]raclopride from dopamine D2 receptor in rat striatal membrane
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and neuropharmacological characterization of 2-O-substituted apomorphines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.34 | 9.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19130 | — | — | 1 | 9.42 |
| CHEMBL18598 | — | — | 1 | 9.37 |
| CHEMBL53445 | — | — | 1 | 8.95 |
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 7.96 |
| CHEMBL276326 | — | — | 1 | 7.75 |
| CHEMBL276042 | — | — | 1 | 7.70 |
| CHEMBL511711 | — | — | 1 | 7.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19130 | — | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL18598 | — | Ki | = | 0.43 | nM | 9.37 |
| CHEMBL53445 | — | Ki | = | 1.12 | nM | 8.95 |
| CHEMBL53 | APOMORPHINE | Ki | = | 11.1 | nM | 7.96 |
| CHEMBL276326 | — | Ki | = | 17.7 | nM | 7.75 |
| CHEMBL276042 | — | Ki | = | 19.9 | nM | 7.70 |
| CHEMBL511711 | — | Ki | = | 54.7 | nM | 7.26 |