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Assay Detail

CHEMBL987102

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human DU145 cells after 24 hrs by fluorometric microculture cytotoxicity assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type DU-145
Confidence 1 — Organism
Curated By Autocuration

Target

DU-145 (CHEMBL613508)
Type CELL-LINE
Organism Homo sapiens

Publication

Hedgehog/GLI-mediated transcriptional inhibitors from Zizyphus cambodiana.
Arai MA, Tateno C, Hosoya T, Koyano T, Kowithayakorn T, Ishibashi M.
Bioorg Med Chem (2008) 16 : 9420 -9424
PubMed 18842418 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 5 4.23 4.43

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL269277 BETULINIC ACID 1.0 1 4.43
CHEMBL511805 ALPHITOLIC ACID 1 4.16
CHEMBL470503 COLUBRINIC ACID 1 4.11
CHEMBL491069 CEANOTHIC ACID 1 -
CHEMBL522108 CEANOTHANOLIC ACID 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL269277 BETULINIC ACID IC50 = 37000.0 nM 4.43
CHEMBL511805 ALPHITOLIC ACID IC50 = 70000.0 nM 4.16
CHEMBL470503 COLUBRINIC ACID IC50 = 78000.0 nM 4.11
CHEMBL491069 CEANOTHIC ACID IC50 > 200000.0 nM -
CHEMBL522108 CEANOTHANOLIC ACID IC50 > 200000.0 nM -