Assay Detail
Binding
CHEMBL987964
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Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of 3-phenylnaphthalenic derivatives as new selective MT(2) melatoninergic ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 8.87 | 9.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL490188 | — | — | 1 | 9.57 |
| CHEMBL10878 | AGOMELATINE | 4.0 | 1 | 9.57 |
| CHEMBL476341 | — | — | 1 | 9.55 |
| CHEMBL476131 | — | — | 1 | 9.44 |
| CHEMBL453138 | — | — | 1 | 9.43 |
| CHEMBL45 | MELATONIN | 4.0 | 1 | 9.39 |
| CHEMBL491604 | — | — | 1 | 9.38 |
| CHEMBL477835 | — | — | 1 | 9.29 |
| CHEMBL518113 | — | — | 1 | 9.28 |
| CHEMBL490595 | — | — | 1 | 9.25 |
| CHEMBL491605 | — | — | 1 | 9.19 |
| CHEMBL477833 | — | — | 1 | 9.15 |
| CHEMBL478217 | — | — | 1 | 9.03 |
| CHEMBL491403 | — | — | 1 | 9.02 |
| CHEMBL517502 | — | — | 1 | 8.73 |
| CHEMBL477834 | — | — | 1 | 8.47 |
| CHEMBL489170 | — | — | 1 | 8.12 |
| CHEMBL478218 | — | — | 1 | 8.08 |
| CHEMBL476132 | — | — | 1 | 7.64 |
| CHEMBL490594 | — | — | 1 | 7.36 |
| CHEMBL478438 | — | — | 1 | 7.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL490188 | — | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL10878 | AGOMELATINE | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL476341 | — | Ki | = | 0.28 | nM | 9.55 |
| CHEMBL476131 | — | Ki | = | 0.36 | nM | 9.44 |
| CHEMBL453138 | — | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL45 | MELATONIN | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL491604 | — | Ki | = | 0.42 | nM | 9.38 |
| CHEMBL477835 | — | Ki | = | 0.51 | nM | 9.29 |
| CHEMBL518113 | — | Ki | = | 0.52 | nM | 9.28 |
| CHEMBL490595 | — | Ki | = | 0.56 | nM | 9.25 |
| CHEMBL491605 | — | Ki | = | 0.64 | nM | 9.19 |
| CHEMBL477833 | — | Ki | = | 0.71 | nM | 9.15 |
| CHEMBL478217 | — | Ki | = | 0.94 | nM | 9.03 |
| CHEMBL491403 | — | Ki | = | 0.95 | nM | 9.02 |
| CHEMBL517502 | — | Ki | = | 1.86 | nM | 8.73 |
| CHEMBL477834 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL489170 | — | Ki | = | 7.54 | nM | 8.12 |
| CHEMBL478218 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL476132 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL490594 | — | Ki | = | 43.3 | nM | 7.36 |
| CHEMBL478438 | — | Ki | = | 48.3 | nM | 7.32 |