Assay Detail
Functional
CHEMBL987966
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of 3-phenylnaphthalenic derivatives as new selective MT(2) melatoninergic ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 9.12 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10878 | AGOMELATINE | 4.0 | 1 | 10.00 |
| CHEMBL45 | MELATONIN | 4.0 | 1 | 9.31 |
| CHEMBL477835 | — | — | 1 | 9.30 |
| CHEMBL476341 | — | — | 1 | 9.22 |
| CHEMBL518113 | — | — | 1 | 9.15 |
| CHEMBL476131 | — | — | 1 | 9.12 |
| CHEMBL490595 | — | — | 1 | 9.00 |
| CHEMBL491604 | — | — | 1 | 8.89 |
| CHEMBL490188 | — | — | 1 | 8.89 |
| CHEMBL478217 | — | — | 1 | 8.82 |
| CHEMBL453138 | — | — | 1 | 8.62 |
| CHEMBL477834 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10878 | AGOMELATINE | EC50 | = | 0.1 | nM | 10.00 |
| CHEMBL45 | MELATONIN | EC50 | = | 0.49 | nM | 9.31 |
| CHEMBL477835 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL476341 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL518113 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL476131 | — | EC50 | = | 0.76 | nM | 9.12 |
| CHEMBL490595 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL491604 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL490188 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL478217 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL453138 | — | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL477834 | — | EC50 | - | — | - |