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Assay Detail

CHEMBL987990

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human DU145 cells assessed as reduction of cell growth by SRB method
25
Total Activities
25
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type DU-145
Confidence 1 — Organism
Curated By Autocuration

Target

DU-145 (CHEMBL613508)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis of unsymmetrical biphenyls as potent cytotoxic agents.
Wu G, Guo HF, Gao K, Liu YN, Bastow KF, Morris-Natschke SL, Lee KH, Xie L.
Bioorg Med Chem Lett (2008) 18 : 5272 -5276
PubMed 18782668 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Activity 13 - -
IC50 12 5.65 7.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL502958 1 7.40
CHEMBL477592 1 6.51
CHEMBL475922 1 5.65
CHEMBL478886 1 5.44
CHEMBL477591 1 5.41
CHEMBL478868 1 5.37
CHEMBL478869 1 5.28
CHEMBL475921 1 5.02
CHEMBL509809 1 4.81
CHEMBL515475 1 -
CHEMBL477194 1 -
CHEMBL518742 1 -
CHEMBL478887 1 -
CHEMBL478888 1 -
CHEMBL516581 1 -
CHEMBL478249 1 -
CHEMBL514857 1 -
CHEMBL477193 1 -
CHEMBL517051 1 -
CHEMBL449679 1 -
CHEMBL479060 1 -
CHEMBL517983 1 -
CHEMBL447624 1 -
CHEMBL478867 1 -
CHEMBL475678 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL502958 IC50 = 40.0 nM 7.40
CHEMBL477592 IC50 = 310.0 nM 6.51
CHEMBL475922 IC50 = 2230.0 nM 5.65
CHEMBL478886 IC50 = 3660.0 nM 5.44
CHEMBL477591 IC50 = 3870.0 nM 5.41
CHEMBL478868 IC50 = 4290.0 nM 5.37
CHEMBL478869 IC50 = 5250.0 nM 5.28
CHEMBL475921 IC50 = 9610.0 nM 5.02
CHEMBL509809 IC50 = 15600.0 nM 4.81
CHEMBL515475 Activity - -
CHEMBL477194 IC50 - -
CHEMBL518742 Activity - -
CHEMBL478887 Activity - -
CHEMBL478888 Activity - -
CHEMBL516581 Activity - -
CHEMBL478249 Activity - -
CHEMBL514857 Activity - -
CHEMBL477193 Activity - -
CHEMBL517051 Activity - -
CHEMBL449679 Activity - -
CHEMBL479060 Activity - -
CHEMBL517983 Activity - -
CHEMBL447624 IC50 - -
CHEMBL478867 IC50 - -
CHEMBL475678 Activity - -