Assay Detail
Binding
CHEMBL988084
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Inhibition of Escherichia coli DHDPS
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
4-hydroxy-tetrahydrodipicolinate synthase (CHEMBL4083) ↗| Type | SINGLE PROTEIN |
| Organism | Escherichia coli K-12 |
Publication
Irreversible inhibition of dihydrodipicolinate synthase by 4-oxo-heptenedioic acid analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 4.80 | 4.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1162545 | GLYOXYLATE | — | 1 | 4.80 |
| CHEMBL1162543 | — | — | 1 | - |
| CHEMBL185075 | — | — | 1 | - |
| CHEMBL1162544 | — | — | 1 | - |
| CHEMBL171246 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1162545 | GLYOXYLATE | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL1162543 | — | Ki | = | 220000.0 | nM | - |
| CHEMBL185075 | — | Ki | = | 170000.0 | nM | - |
| CHEMBL1162544 | — | Ki | = | 700000.0 | nM | - |
| CHEMBL171246 | — | Ki | = | 830000.0 | nM | - |