Assay Detail
Binding
CHEMBL989836
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Inhibition of human CYP11B1 expressed in hamster V79 MZh cells
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | V79 MZh |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.08 | 8.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL451505 | — | — | 1 | 8.16 |
| CHEMBL9298 | FADROZOLE | 2.0 | 1 | 8.00 |
| CHEMBL456390 | — | — | 1 | 7.48 |
| CHEMBL457856 | — | — | 1 | 7.06 |
| CHEMBL499007 | — | — | 1 | 6.72 |
| CHEMBL461884 | — | — | 1 | 6.54 |
| CHEMBL457646 | — | — | 1 | 6.47 |
| CHEMBL509971 | — | — | 1 | 6.28 |
| CHEMBL511329 | — | — | 1 | 6.24 |
| CHEMBL459970 | — | — | 1 | 6.13 |
| CHEMBL446083 | — | — | 1 | 6.13 |
| CHEMBL508155 | — | — | 1 | 6.11 |
| CHEMBL448743 | — | — | 1 | 6.09 |
| CHEMBL460178 | — | — | 1 | 5.94 |
| CHEMBL457640 | — | — | 1 | 5.78 |
| CHEMBL461457 | — | — | 1 | 5.70 |
| CHEMBL462093 | — | — | 1 | 5.40 |
| CHEMBL459969 | — | — | 1 | 5.36 |
| CHEMBL461458 | — | — | 1 | 5.31 |
| CHEMBL457425 | — | — | 1 | 5.29 |
| CHEMBL457858 | — | — | 1 | 5.27 |
| CHEMBL459071 | — | — | 1 | 5.22 |
| CHEMBL461885 | — | — | 1 | 5.22 |
| CHEMBL62811 | — | — | 1 | 5.17 |
| CHEMBL462092 | — | — | 1 | 4.87 |
| CHEMBL457639 | — | — | 1 | - |
| CHEMBL456391 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL451505 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL9298 | FADROZOLE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL456390 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL457856 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL499007 | — | IC50 | = | 191.0 | nM | 6.72 |
| CHEMBL461884 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL457646 | — | IC50 | = | 339.0 | nM | 6.47 |
| CHEMBL509971 | — | IC50 | = | 525.0 | nM | 6.28 |
| CHEMBL511329 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL459970 | — | IC50 | = | 745.0 | nM | 6.13 |
| CHEMBL446083 | — | IC50 | = | 742.0 | nM | 6.13 |
| CHEMBL508155 | — | IC50 | = | 769.0 | nM | 6.11 |
| CHEMBL448743 | — | IC50 | = | 819.0 | nM | 6.09 |
| CHEMBL460178 | — | IC50 | = | 1145.0 | nM | 5.94 |
| CHEMBL457640 | — | IC50 | = | 1671.0 | nM | 5.78 |
| CHEMBL461457 | — | IC50 | = | 1977.0 | nM | 5.70 |
| CHEMBL462093 | — | IC50 | = | 3964.0 | nM | 5.40 |
| CHEMBL459969 | — | IC50 | = | 4371.0 | nM | 5.36 |
| CHEMBL461458 | — | IC50 | = | 4921.0 | nM | 5.31 |
| CHEMBL457425 | — | IC50 | = | 5177.0 | nM | 5.29 |
| CHEMBL457858 | — | IC50 | = | 5402.0 | nM | 5.27 |
| CHEMBL459071 | — | IC50 | = | 5952.0 | nM | 5.22 |
| CHEMBL461885 | — | IC50 | = | 5970.0 | nM | 5.22 |
| CHEMBL62811 | — | IC50 | = | 6746.0 | nM | 5.17 |
| CHEMBL462092 | — | IC50 | = | 13378.0 | nM | 4.87 |
| CHEMBL457639 | — | IC50 | - | — | - | |
| CHEMBL456391 | — | IC50 | - | — | - |