Assay Detail
Functional
CHEMBL990631
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Anticancer activity against human DU145 cells after 72 hrs by XTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Semisynthesis and antitumoral activity of 2-acetylfuranonaphthoquinone and other naphthoquinone derivatives from lapachol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.81 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 8.41 |
| CHEMBL15192 | LAPACHONE | 2.0 | 1 | 8.13 |
| CHEMBL485229 | — | — | 1 | 8.06 |
| CHEMBL483371 | — | — | 1 | 7.95 |
| CHEMBL221630 | DEHYDROISO-ALPHA-LAPACHONE | — | 1 | 7.93 |
| CHEMBL374570 | — | — | 1 | 7.81 |
| CHEMBL484359 | — | — | 1 | 7.70 |
| CHEMBL64130 | NAPABUCASIN | 3.0 | 1 | 7.64 |
| CHEMBL485230 | — | — | 1 | 7.32 |
| CHEMBL15193 | LAPACHOL | — | 1 | 7.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL15192 | LAPACHONE | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL485229 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL483371 | — | IC50 | = | 11.14 | nM | 7.95 |
| CHEMBL221630 | DEHYDROISO-ALPHA-LAPACHONE | IC50 | = | 11.67 | nM | 7.93 |
| CHEMBL374570 | — | IC50 | = | 15.37 | nM | 7.81 |
| CHEMBL484359 | — | IC50 | = | 19.87 | nM | 7.70 |
| CHEMBL64130 | NAPABUCASIN | IC50 | = | 23.04 | nM | 7.64 |
| CHEMBL485230 | — | IC50 | = | 48.37 | nM | 7.32 |
| CHEMBL15193 | LAPACHOL | IC50 | = | 64.59 | nM | 7.19 |