Assay Detail
Binding
CHEMBL990750
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Inhibition of active form of human liver glycogen phosphorylase
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and pharmacological evaluation of N-bicyclo-5-chloro-1H-indole-2-carboxamide derivatives as potent glycogen phosphorylase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.49 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL458289 | — | — | 1 | 7.70 |
| CHEMBL457860 | — | — | 1 | 7.44 |
| CHEMBL457650 | — | — | 1 | 7.32 |
| CHEMBL457643 | — | — | 1 | 7.20 |
| CHEMBL444029 | — | — | 1 | 7.17 |
| CHEMBL457861 | — | — | 1 | 6.80 |
| CHEMBL457877 | — | — | 1 | 6.50 |
| CHEMBL458092 | — | — | 1 | 6.36 |
| CHEMBL505339 | — | — | 1 | 6.23 |
| CHEMBL457029 | — | — | 1 | 6.10 |
| CHEMBL455988 | — | — | 1 | 6.09 |
| CHEMBL458091 | — | — | 1 | 6.05 |
| CHEMBL99889 | — | — | 1 | 6.04 |
| CHEMBL457878 | — | — | 1 | 5.92 |
| CHEMBL496723 | — | — | 1 | 5.80 |
| CHEMBL513263 | — | — | 1 | 5.07 |
| CHEMBL459139 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL458289 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL457860 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL457650 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL457643 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL444029 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL457861 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL457877 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL458092 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL505339 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL457029 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL455988 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL458091 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL99889 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL457878 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL496723 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL513263 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL459139 | — | IC50 | > | 10000.0 | nM | - |