Assay Detail
Functional
CHEMBL991034
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Antiviral activity against VZV Webster by plaque reduction assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of 4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxamides with broad-spectrum human herpesvirus polymerase inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.61 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL481172 | — | — | 1 | 7.70 |
| CHEMBL479371 | — | — | 1 | 7.05 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 5.09 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL481172 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL479371 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL184 | ACYCLOVIR | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL182 | GANCICLOVIR | IC50 | - | — | - |