Assay Detail
Binding
CHEMBL992474
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]5-HT from SERT in rat cerebral cortex synaptosome membrane
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
The molecular interactions of buspirone analogues with the serotonin transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.08 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL485540 | — | — | 1 | 7.48 |
| CHEMBL485542 | — | — | 1 | 7.12 |
| CHEMBL483176 | — | — | 1 | 7.02 |
| CHEMBL299638 | — | — | 1 | 6.95 |
| CHEMBL297702 | — | — | 1 | 6.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL485540 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL485542 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL483176 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL299638 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL297702 | — | IC50 | = | 146.0 | nM | 6.84 |