Assay Detail
Binding
CHEMBL992601
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Inhibition of candida albicans isocitrate lyase
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Candida albicans |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibition of Candida albicans isocitrate lyase activity by sesterterpene sulfates from the tropical sponge Dysidea sp.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.28 | 4.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL492072 | — | — | 1 | 4.50 |
| CHEMBL483377 | — | — | 1 | 4.47 |
| CHEMBL451226 | — | — | 1 | 4.29 |
| CHEMBL491665 | — | — | 1 | 4.15 |
| CHEMBL387584 | HALISULFATE 1 | — | 1 | 4.15 |
| CHEMBL484372 | — | — | 1 | 4.12 |
| CHEMBL450482 | — | — | 1 | - |
| CHEMBL484213 | — | — | 1 | - |
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL492072 | — | IC50 | = | 31300.0 | nM | 4.50 |
| CHEMBL483377 | — | IC50 | = | 33800.0 | nM | 4.47 |
| CHEMBL451226 | — | IC50 | = | 50700.0 | nM | 4.29 |
| CHEMBL491665 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL387584 | HALISULFATE 1 | IC50 | = | 70200.0 | nM | 4.15 |
| CHEMBL484372 | — | IC50 | = | 76800.0 | nM | 4.12 |
| CHEMBL450482 | — | IC50 | = | 157500.0 | nM | - |
| CHEMBL484213 | — | IC50 | = | 185500.0 | nM | - |
| CHEMBL267345 | AMPHOTERICIN B | IC50 | - | — | - |