Assay Detail
Binding
CHEMBL992753
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human SERT
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.31 | 7.28 |
Compounds Tested
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL708 | ZIPRASIDONE | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL476108 | — | Ki | = | 56.6 | nM | 7.25 |
| CHEMBL85 | RISPERIDONE | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL42 | CLOZAPINE | Ki | = | 3900.0 | nM | 5.41 |
| CHEMBL716 | QUETIAPINE | Ki | > | 18000.0 | nM | - |
| CHEMBL715 | OLANZAPINE | Ki | > | 15000.0 | nM | - |