Assay Detail
Binding
CHEMBL992813
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Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological characterization of chiral pyrrolidinylfuran derivatives: the discovery of new functionally selective muscarinic agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 5.08 | 6.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92387 | — | — | 1 | 6.02 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 5.91 |
| CHEMBL551563 | — | — | 1 | 5.78 |
| CHEMBL555475 | — | — | 1 | 5.72 |
| CHEMBL553434 | — | — | 1 | 5.57 |
| CHEMBL40554 | — | — | 1 | 5.49 |
| CHEMBL461089 | — | — | 1 | 5.49 |
| CHEMBL554532 | — | — | 1 | 5.43 |
| CHEMBL505086 | — | — | 1 | 5.37 |
| CHEMBL553155 | — | — | 1 | 5.13 |
| CHEMBL527880 | — | — | 1 | 4.85 |
| CHEMBL513277 | — | — | 1 | 4.84 |
| CHEMBL450463 | — | — | 1 | 4.80 |
| CHEMBL461709 | — | — | 1 | 4.71 |
| CHEMBL458416 | — | — | 1 | 4.54 |
| CHEMBL461087 | — | — | 1 | 4.53 |
| CHEMBL450729 | — | — | 1 | 4.51 |
| CHEMBL460470 | — | — | 1 | 4.38 |
| CHEMBL461502 | — | — | 1 | 4.32 |
| CHEMBL461088 | — | — | 1 | 4.11 |
| CHEMBL451335 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92387 | — | Ki | = | 954.99 | nM | 6.02 |
| CHEMBL14 | CARBACHOL | Ki | = | 1230.27 | nM | 5.91 |
| CHEMBL551563 | — | Ki | = | 1659.59 | nM | 5.78 |
| CHEMBL555475 | — | Ki | = | 1905.46 | nM | 5.72 |
| CHEMBL553434 | — | Ki | = | 2691.53 | nM | 5.57 |
| CHEMBL40554 | — | Ki | = | 3235.94 | nM | 5.49 |
| CHEMBL461089 | — | Ki | = | 3235.94 | nM | 5.49 |
| CHEMBL554532 | — | Ki | = | 3715.35 | nM | 5.43 |
| CHEMBL505086 | — | Ki | = | 4265.8 | nM | 5.37 |
| CHEMBL553155 | — | Ki | = | 7413.1 | nM | 5.13 |
| CHEMBL527880 | — | Ki | = | 14125.38 | nM | 4.85 |
| CHEMBL513277 | — | Ki | = | 14454.4 | nM | 4.84 |
| CHEMBL450463 | — | Ki | = | 15848.93 | nM | 4.80 |
| CHEMBL461709 | — | Ki | = | 19498.45 | nM | 4.71 |
| CHEMBL458416 | — | Ki | = | 28840.32 | nM | 4.54 |
| CHEMBL461087 | — | Ki | = | 29512.09 | nM | 4.53 |
| CHEMBL450729 | — | Ki | = | 30902.95 | nM | 4.51 |
| CHEMBL460470 | — | Ki | = | 41686.94 | nM | 4.38 |
| CHEMBL461502 | — | Ki | = | 47863.01 | nM | 4.32 |
| CHEMBL461088 | — | Ki | = | 77624.71 | nM | 4.11 |
| CHEMBL451335 | — | Ki | = | 107151.93 | nM | - |