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Compound Detail

CHEMBL513277

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Cc1ccc(C2CCCN2C)o1

Basic Information

ChEMBL ID CHEMBL513277
Phase Preclinical
Structure Type MOL
InChI Key NTRCVGKENRJOLL-UHFFFAOYSA-N
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

165.2
MW (Da)
2.35
ALogP
2
HBA
0
HBD
16.4
PSA (Ų)
0.63
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C10H15NO
MW 165.24
Aromatic Rings 1
Heavy Atoms 12
NP-Likeness -0.50

Activity Summary

Ki 5 meas. best 4.84

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M2
CHEMBL211
Ki 4.84 4.84 14454.4 1
Muscarinic acetylcholine receptor M5
CHEMBL2035
Ki 4.66 4.66 21877.6 1
Muscarinic acetylcholine receptor M3
CHEMBL245
Ki 4.64 4.64 22908.7 1
Muscarinic acetylcholine receptor M4
CHEMBL1821
Ki 4.61 4.61 24547.1 1
Muscarinic acetylcholine receptor M1
CHEMBL216
Ki 4.57 4.57 26915.3 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
18543900 10.1021/jm800145d Unchecked 6
18543900 10.1021/jm800145d Muscarinic acetylcholine receptor M1 1
18543900 10.1021/jm800145d Muscarinic acetylcholine receptor M2 1
18543900 10.1021/jm800145d Muscarinic acetylcholine receptor M3 1
18543900 10.1021/jm800145d Muscarinic acetylcholine receptor M4 1
18543900 10.1021/jm800145d Muscarinic acetylcholine receptor M5 1

Data from ChEMBL 36 via Core Engine