Assay Detail
Binding
CHEMBL992812
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Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO cells by liquid scintillation counter
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological characterization of chiral pyrrolidinylfuran derivatives: the discovery of new functionally selective muscarinic agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 4.67 | 5.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL40554 | — | — | 1 | 5.71 |
| CHEMBL554532 | — | — | 1 | 5.28 |
| CHEMBL551563 | — | — | 1 | 5.25 |
| CHEMBL555475 | — | — | 1 | 5.13 |
| CHEMBL92387 | — | — | 1 | 5.10 |
| CHEMBL553434 | — | — | 1 | 4.86 |
| CHEMBL461089 | — | — | 1 | 4.84 |
| CHEMBL513277 | — | — | 1 | 4.57 |
| CHEMBL553155 | — | — | 1 | 4.51 |
| CHEMBL460470 | — | — | 1 | 4.48 |
| CHEMBL450463 | — | — | 1 | 4.44 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 4.42 |
| CHEMBL505086 | — | — | 1 | 4.42 |
| CHEMBL450729 | — | — | 1 | 4.36 |
| CHEMBL461709 | — | — | 1 | 4.35 |
| CHEMBL461088 | — | — | 1 | 4.33 |
| CHEMBL527880 | — | — | 1 | 4.29 |
| CHEMBL451335 | — | — | 1 | 4.20 |
| CHEMBL461502 | — | — | 1 | 4.11 |
| CHEMBL461087 | — | — | 1 | - |
| CHEMBL458416 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL40554 | — | Ki | = | 1949.84 | nM | 5.71 |
| CHEMBL554532 | — | Ki | = | 5248.07 | nM | 5.28 |
| CHEMBL551563 | — | Ki | = | 5623.41 | nM | 5.25 |
| CHEMBL555475 | — | Ki | = | 7413.1 | nM | 5.13 |
| CHEMBL92387 | — | Ki | = | 7943.28 | nM | 5.10 |
| CHEMBL553434 | — | Ki | = | 13803.84 | nM | 4.86 |
| CHEMBL461089 | — | Ki | = | 14454.4 | nM | 4.84 |
| CHEMBL513277 | — | Ki | = | 26915.35 | nM | 4.57 |
| CHEMBL553155 | — | Ki | = | 30902.95 | nM | 4.51 |
| CHEMBL460470 | — | Ki | = | 33113.11 | nM | 4.48 |
| CHEMBL450463 | — | Ki | = | 36307.81 | nM | 4.44 |
| CHEMBL14 | CARBACHOL | Ki | = | 38018.94 | nM | 4.42 |
| CHEMBL505086 | — | Ki | = | 38018.94 | nM | 4.42 |
| CHEMBL450729 | — | Ki | = | 43651.58 | nM | 4.36 |
| CHEMBL461709 | — | Ki | = | 44668.36 | nM | 4.35 |
| CHEMBL461088 | — | Ki | = | 46773.51 | nM | 4.33 |
| CHEMBL527880 | — | Ki | = | 51286.14 | nM | 4.29 |
| CHEMBL451335 | — | Ki | = | 63095.73 | nM | 4.20 |
| CHEMBL461502 | — | Ki | = | 77624.71 | nM | 4.11 |
| CHEMBL461087 | — | Ki | = | 177827.94 | nM | - |
| CHEMBL458416 | — | Ki | = | 154881.66 | nM | - |