Assay Detail
Binding
CHEMBL992816
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Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells by liquid scintillation counter
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor M5 (CHEMBL2035) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and pharmacological characterization of chiral pyrrolidinylfuran derivatives: the discovery of new functionally selective muscarinic agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 4.73 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL554532 | — | — | 1 | 5.50 |
| CHEMBL551563 | — | — | 1 | 5.44 |
| CHEMBL40554 | — | — | 1 | 5.42 |
| CHEMBL555475 | — | — | 1 | 5.33 |
| CHEMBL92387 | — | — | 1 | 5.16 |
| CHEMBL553434 | — | — | 1 | 5.02 |
| CHEMBL461089 | — | — | 1 | 4.80 |
| CHEMBL461087 | — | — | 1 | 4.78 |
| CHEMBL505086 | — | — | 1 | 4.72 |
| CHEMBL553155 | — | — | 1 | 4.68 |
| CHEMBL513277 | — | — | 1 | 4.66 |
| CHEMBL527880 | — | — | 1 | 4.63 |
| CHEMBL461088 | — | — | 1 | 4.50 |
| CHEMBL461709 | — | — | 1 | 4.50 |
| CHEMBL450463 | — | — | 1 | 4.40 |
| CHEMBL460470 | — | — | 1 | 4.35 |
| CHEMBL451335 | — | — | 1 | 4.32 |
| CHEMBL450729 | — | — | 1 | 4.20 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 4.16 |
| CHEMBL461502 | — | — | 1 | 4.12 |
| CHEMBL458416 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL554532 | — | Ki | = | 3162.28 | nM | 5.50 |
| CHEMBL551563 | — | Ki | = | 3630.78 | nM | 5.44 |
| CHEMBL40554 | — | Ki | = | 3801.89 | nM | 5.42 |
| CHEMBL555475 | — | Ki | = | 4677.35 | nM | 5.33 |
| CHEMBL92387 | — | Ki | = | 6918.31 | nM | 5.16 |
| CHEMBL553434 | — | Ki | = | 9549.93 | nM | 5.02 |
| CHEMBL461089 | — | Ki | = | 15848.93 | nM | 4.80 |
| CHEMBL461087 | — | Ki | = | 16595.87 | nM | 4.78 |
| CHEMBL505086 | — | Ki | = | 19054.61 | nM | 4.72 |
| CHEMBL553155 | — | Ki | = | 20892.96 | nM | 4.68 |
| CHEMBL513277 | — | Ki | = | 21877.62 | nM | 4.66 |
| CHEMBL527880 | — | Ki | = | 23442.29 | nM | 4.63 |
| CHEMBL461088 | — | Ki | = | 31622.78 | nM | 4.50 |
| CHEMBL461709 | — | Ki | = | 31622.78 | nM | 4.50 |
| CHEMBL450463 | — | Ki | = | 39810.72 | nM | 4.40 |
| CHEMBL460470 | — | Ki | = | 44668.36 | nM | 4.35 |
| CHEMBL451335 | — | Ki | = | 47863.01 | nM | 4.32 |
| CHEMBL450729 | — | Ki | = | 63095.73 | nM | 4.20 |
| CHEMBL14 | CARBACHOL | Ki | = | 69183.1 | nM | 4.16 |
| CHEMBL461502 | — | Ki | = | 75857.76 | nM | 4.12 |
| CHEMBL458416 | — | Ki | = | 138038.43 | nM | - |