Assay Detail
Binding
CHEMBL992815
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Displacement of [3H]NMS from human muscarinic M4 receptor expressed in CHO cells by liquid scintillation counter
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor M4 (CHEMBL1821) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and pharmacological characterization of chiral pyrrolidinylfuran derivatives: the discovery of new functionally selective muscarinic agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 4.63 | 5.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL555475 | — | — | 1 | 5.36 |
| CHEMBL551563 | — | — | 1 | 5.29 |
| CHEMBL92387 | — | — | 1 | 5.20 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 5.20 |
| CHEMBL554532 | — | — | 1 | 5.19 |
| CHEMBL40554 | — | — | 1 | 5.04 |
| CHEMBL553434 | — | — | 1 | 4.86 |
| CHEMBL553155 | — | — | 1 | 4.67 |
| CHEMBL513277 | — | — | 1 | 4.61 |
| CHEMBL527880 | — | — | 1 | 4.55 |
| CHEMBL461089 | — | — | 1 | 4.53 |
| CHEMBL450463 | — | — | 1 | 4.32 |
| CHEMBL505086 | — | — | 1 | 4.29 |
| CHEMBL450729 | — | — | 1 | 4.25 |
| CHEMBL461709 | — | — | 1 | 4.23 |
| CHEMBL460470 | — | — | 1 | 4.16 |
| CHEMBL461502 | — | — | 1 | 4.10 |
| CHEMBL461087 | — | — | 1 | 4.06 |
| CHEMBL461088 | — | — | 1 | 4.05 |
| CHEMBL458416 | — | — | 1 | - |
| CHEMBL451335 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL555475 | — | Ki | = | 4365.16 | nM | 5.36 |
| CHEMBL551563 | — | Ki | = | 5128.61 | nM | 5.29 |
| CHEMBL92387 | — | Ki | = | 6309.57 | nM | 5.20 |
| CHEMBL14 | CARBACHOL | Ki | = | 6309.57 | nM | 5.20 |
| CHEMBL554532 | — | Ki | = | 6456.54 | nM | 5.19 |
| CHEMBL40554 | — | Ki | = | 9120.11 | nM | 5.04 |
| CHEMBL553434 | — | Ki | = | 13803.84 | nM | 4.86 |
| CHEMBL553155 | — | Ki | = | 21379.62 | nM | 4.67 |
| CHEMBL513277 | — | Ki | = | 24547.09 | nM | 4.61 |
| CHEMBL527880 | — | Ki | = | 28183.83 | nM | 4.55 |
| CHEMBL461089 | — | Ki | = | 29512.09 | nM | 4.53 |
| CHEMBL450463 | — | Ki | = | 47863.01 | nM | 4.32 |
| CHEMBL505086 | — | Ki | = | 51286.14 | nM | 4.29 |
| CHEMBL450729 | — | Ki | = | 56234.13 | nM | 4.25 |
| CHEMBL461709 | — | Ki | = | 58884.37 | nM | 4.23 |
| CHEMBL460470 | — | Ki | = | 69183.1 | nM | 4.16 |
| CHEMBL461502 | — | Ki | = | 79432.82 | nM | 4.10 |
| CHEMBL461087 | — | Ki | = | 87096.36 | nM | 4.06 |
| CHEMBL461088 | — | Ki | = | 89125.09 | nM | 4.05 |
| CHEMBL458416 | — | Ki | = | 208929.61 | nM | - |
| CHEMBL451335 | — | Ki | = | 102329.3 | nM | - |