Assay Detail
Binding
CHEMBL993513
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DAMGO from mu opioid receptor expressed in CHO cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
14-O-Heterocyclic-substituted naltrexone derivatives as non-peptide mu opioid receptor selective antagonists: design, synthesis, and biological studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 8.43 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL476600 | — | — | 1 | 9.85 |
| CHEMBL19019 | NALTREXONE | 4.0 | 1 | 9.59 |
| CHEMBL473136 | — | — | 1 | 9.39 |
| CHEMBL472843 | — | — | 1 | 8.84 |
| CHEMBL476603 | — | — | 1 | 8.80 |
| CHEMBL500766 | — | — | 1 | 8.70 |
| CHEMBL473253 | — | — | 1 | 8.57 |
| CHEMBL515621 | — | — | 1 | 8.25 |
| CHEMBL516085 | — | — | 1 | 7.17 |
| CHEMBL516263 | — | — | 1 | 6.91 |
| CHEMBL513990 | — | — | 1 | 6.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL476600 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL19019 | NALTREXONE | Ki | = | 0.26 | nM | 9.59 |
| CHEMBL473136 | — | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL472843 | — | Ki | = | 1.44 | nM | 8.84 |
| CHEMBL476603 | — | Ki | = | 1.59 | nM | 8.80 |
| CHEMBL500766 | — | Ki | = | 2.02 | nM | 8.70 |
| CHEMBL473253 | — | Ki | = | 2.69 | nM | 8.57 |
| CHEMBL515621 | — | Ki | = | 5.58 | nM | 8.25 |
| CHEMBL516085 | — | Ki | = | 68.4 | nM | 7.17 |
| CHEMBL516263 | — | Ki | = | 123.23 | nM | 6.91 |
| CHEMBL513990 | — | Ki | = | 225.27 | nM | 6.65 |