Assay Detail
Functional
CHEMBL993519
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Antagonist activity against mu opioid receptor expressed in CHO cells assessed as inhibition of DAMGO-induced stimulation of [35S]GTPgammaS binding
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
14-O-Heterocyclic-substituted naltrexone derivatives as non-peptide mu opioid receptor selective antagonists: design, synthesis, and biological studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ke | 1 | - | - |
| Kd | 1 | 9.72 | 9.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL476600 | — | — | 2 | 9.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL476600 | — | Kd | = | 0.1905 | nM | 9.72 |
| CHEMBL476600 | — | Ke | = | 0.2 | nM | - |