Assay Detail
Binding
CHEMBL993536
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Displacement of [11C]PK11195 from PBR receptor in rat brain membrane
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
[18F]FEAC and [18F]FEDAC: Two novel positron emission tomography ligands for peripheral-type benzodiazepine receptor in the brain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 9.34 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL513922 | EMAPUNIL | 2.0 | 1 | 9.70 |
| CHEMBL481537 | PK-11195 | — | 1 | 9.51 |
| CHEMBL515622 | — | — | 1 | 9.31 |
| CHEMBL476811 | — | — | 1 | 9.29 |
| CHEMBL476607 | — | — | 1 | 8.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL513922 | EMAPUNIL | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL481537 | PK-11195 | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL515622 | — | Ki | = | 0.49 | nM | 9.31 |
| CHEMBL476811 | — | Ki | = | 0.51 | nM | 9.29 |
| CHEMBL476607 | — | Ki | = | 1.34 | nM | 8.87 |