Assay Detail
Binding
CHEMBL993579
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Inhibition of maltase in human Caco-2 cell model system after 2 hrs
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Caco-2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.54 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307429 | DUVOGLUSTAT | 2.0 | 1 | 7.22 |
| CHEMBL476960 | VOGLIBOSE | 4.0 | 1 | 7.16 |
| CHEMBL501355 | — | — | 1 | 7.00 |
| CHEMBL1561 | MIGLITOL | 4.0 | 1 | 6.00 |
| CHEMBL404271 | ACARBOSE | 4.0 | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307429 | DUVOGLUSTAT | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL476960 | VOGLIBOSE | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL501355 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1561 | MIGLITOL | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL404271 | ACARBOSE | IC50 | = | 5000.0 | nM | 5.30 |