Assay Detail
Functional
CHEMBL994255
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Induction of apoptosis in human T47D cells assessed as caspase 3 activation by HTS assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T47D |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 4-aryl-2-oxo-2H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 7.20 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL399124 | — | — | 1 | 8.70 |
| CHEMBL515623 | — | — | 1 | 7.89 |
| CHEMBL477383 | — | — | 1 | 7.77 |
| CHEMBL196832 | — | — | 1 | 7.72 |
| CHEMBL476982 | — | — | 1 | 7.72 |
| CHEMBL477186 | — | — | 1 | 7.62 |
| CHEMBL445486 | — | — | 1 | 7.62 |
| CHEMBL476761 | — | — | 1 | 7.57 |
| CHEMBL515320 | — | — | 1 | 7.38 |
| CHEMBL477814 | — | — | 1 | 7.37 |
| CHEMBL477815 | — | — | 1 | 7.37 |
| CHEMBL477384 | — | — | 1 | 7.28 |
| CHEMBL373137 | — | — | 1 | 7.14 |
| CHEMBL477189 | — | — | 1 | 6.55 |
| CHEMBL477188 | — | — | 1 | 6.09 |
| CHEMBL477395 | — | — | 1 | 5.52 |
| CHEMBL477394 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL399124 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL515623 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL477383 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL196832 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL476982 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL477186 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL445486 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL476761 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL515320 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL477814 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL477815 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL477384 | — | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL373137 | — | EC50 | = | 73.0 | nM | 7.14 |
| CHEMBL477189 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL477188 | — | EC50 | = | 820.0 | nM | 6.09 |
| CHEMBL477395 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL477394 | — | EC50 | = | 6900.0 | nM | 5.16 |