Assay Detail
Functional
CHEMBL994490
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level
19
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transient receptor potential cation channel subfamily V member 1 (CHEMBL4794) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Conformationally constrained fatty acid ethanolamides as cannabinoid and vanilloid receptor probes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 6.75 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL559612 | CP-55940 | — | 1 | 8.00 |
| CHEMBL472662 | — | — | 2 | 7.89 |
| CHEMBL483144 | — | — | 1 | 7.72 |
| CHEMBL294199 | CAPSAICIN | 4.0 | 1 | 7.70 |
| CHEMBL475904 | — | — | 2 | 7.64 |
| CHEMBL485197 | — | — | 1 | 7.40 |
| CHEMBL485369 | — | — | 1 | 7.33 |
| CHEMBL472661 | — | — | 2 | 6.82 |
| CHEMBL483143 | — | — | 1 | 6.75 |
| CHEMBL15848 | ANANDAMIDE | — | 1 | 6.70 |
| CHEMBL474488 | — | — | 2 | 6.21 |
| CHEMBL485368 | — | — | 1 | 5.62 |
| CHEMBL280065 | OLEOYLETHANOLAMIDE | — | 1 | 5.44 |
| CHEMBL484344 | — | — | 1 | 4.58 |
| CHEMBL417675 | PALMIDROL | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL559612 | CP-55940 | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL472662 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL483144 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL294199 | CAPSAICIN | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL475904 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL485197 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL485369 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL475904 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL472662 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL472661 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL483143 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL15848 | ANANDAMIDE | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL474488 | — | EC50 | = | 610.0 | nM | 6.21 |
| CHEMBL474488 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL485368 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL280065 | OLEOYLETHANOLAMIDE | EC50 | = | 3650.0 | nM | 5.44 |
| CHEMBL472661 | — | EC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL484344 | — | EC50 | = | 26400.0 | nM | 4.58 |
| CHEMBL417675 | PALMIDROL | EC50 | > | 10000.0 | nM | - |