Assay Detail
ADMET
CHEMBL995203
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Inhibition of recombinant CYP3A4 by microtiter plate-based fluorimetric assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Zwitterionic uracil derivatives as potent GnRH receptor antagonists with improved pharmaceutical properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.02 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434936 | — | — | 1 | 7.00 |
| CHEMBL503624 | — | — | 1 | 6.46 |
| CHEMBL455769 | — | — | 1 | 6.29 |
| CHEMBL505033 | — | — | 1 | 5.09 |
| CHEMBL447424 | — | — | 1 | 5.00 |
| CHEMBL506338 | — | — | 1 | 5.00 |
| CHEMBL448253 | — | — | 1 | 5.00 |
| CHEMBL451916 | — | — | 1 | 4.89 |
| CHEMBL449468 | — | — | 1 | 4.66 |
| CHEMBL509347 | — | — | 1 | 4.66 |
| CHEMBL444989 | — | — | 1 | 4.60 |
| CHEMBL454774 | — | — | 1 | 4.55 |
| CHEMBL499442 | — | — | 1 | 4.48 |
| CHEMBL448656 | — | — | 1 | 4.44 |
| CHEMBL509075 | — | — | 1 | 4.44 |
| CHEMBL499849 | — | — | 1 | 4.44 |
| CHEMBL509267 | — | — | 1 | 4.38 |
| CHEMBL453441 | — | — | 1 | - |
| CHEMBL502967 | — | — | 1 | - |
| CHEMBL450414 | — | — | 1 | - |
| CHEMBL452198 | — | — | 1 | - |
| CHEMBL452474 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434936 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL503624 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL455769 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL505033 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL447424 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL506338 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL448253 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL451916 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL449468 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL509347 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL444989 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL454774 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL499442 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL448656 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL509075 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL499849 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL509267 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL453441 | — | IC50 | - | — | - | |
| CHEMBL502967 | — | IC50 | - | — | - | |
| CHEMBL450414 | — | IC50 | - | — | - | |
| CHEMBL452198 | — | IC50 | - | — | - | |
| CHEMBL452474 | — | IC50 | - | — | - |