Assay Detail
ADMET
CHEMBL995611
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Inhibition of CYP3A4
27
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Potent and orally bioavailable zwitterion GnRH antagonists with low CYP3A4 inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.68 | 7.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL508435 | — | — | 1 | 7.32 |
| CHEMBL434936 | — | — | 1 | 7.00 |
| CHEMBL499026 | — | — | 1 | 6.92 |
| CHEMBL445691 | — | — | 1 | 6.89 |
| CHEMBL189164 | — | — | 1 | 6.80 |
| CHEMBL371613 | — | — | 1 | 6.75 |
| CHEMBL365985 | — | — | 1 | 6.52 |
| CHEMBL503624 | — | — | 1 | 6.46 |
| CHEMBL364914 | — | — | 1 | 6.42 |
| CHEMBL192172 | — | — | 1 | 6.36 |
| CHEMBL455769 | — | — | 1 | 6.29 |
| CHEMBL191817 | — | — | 1 | 6.22 |
| CHEMBL499307 | — | — | 1 | 6.17 |
| CHEMBL495882 | — | — | 1 | 6.10 |
| CHEMBL497747 | — | — | 1 | 5.04 |
| CHEMBL499589 | — | — | 1 | 4.80 |
| CHEMBL450471 | — | — | 2 | 4.80 |
| CHEMBL499588 | — | — | 1 | 4.70 |
| CHEMBL526887 | — | — | 1 | 4.70 |
| CHEMBL456279 | — | — | 1 | 4.51 |
| CHEMBL526327 | — | — | 1 | 4.48 |
| CHEMBL499849 | — | — | 1 | 4.44 |
| CHEMBL509075 | — | — | 2 | 4.44 |
| CHEMBL508020 | — | — | 1 | 4.32 |
| CHEMBL453167 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL508435 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL434936 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL499026 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL445691 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL189164 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL371613 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL365985 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL503624 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL364914 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL192172 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL455769 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL191817 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL499307 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL495882 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL497747 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL450471 | — | IC50 | = | 15848.93 | nM | 4.80 |
| CHEMBL499589 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL450471 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL499588 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL526887 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL456279 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL526327 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL499849 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL509075 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL509075 | — | IC50 | = | 39810.72 | nM | 4.40 |
| CHEMBL508020 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL453167 | — | IC50 | > | 50000.0 | nM | - |