Assay Detail
Binding
CHEMBL995702
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cyclooxygenase activity of COX1 in sheep seminal vesicle in presence of 1 mM phenol by cyclooxygenase assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Tissue | Seminal vesicle |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Mechanism-based inactivation of COX-1 by red wine m-hydroquinones: a structure-activity relationship study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.62 | 4.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL583912 | (-)-EPICATECHIN | 2.0 | 1 | 4.91 |
| CHEMBL129482 | (+)-EPICATECHIN | 2.0 | 1 | 4.89 |
| CHEMBL311498 | CIANIDANOL | 4.0 | 1 | 4.70 |
| CHEMBL200715 | (-)-CATECHIN | — | 1 | 4.51 |
| CHEMBL24147 | RESORCINOL | -1.0 | 1 | 4.51 |
| CHEMBL165 | RESVERATROL | 3.0 | 1 | 4.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL583912 | (-)-EPICATECHIN | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL129482 | (+)-EPICATECHIN | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL311498 | CIANIDANOL | IC50 | = | 20200.0 | nM | 4.70 |
| CHEMBL200715 | (-)-CATECHIN | IC50 | = | 30800.0 | nM | 4.51 |
| CHEMBL24147 | RESORCINOL | IC50 | = | 30800.0 | nM | 4.51 |
| CHEMBL165 | RESVERATROL | IC50 | = | 67300.0 | nM | 4.17 |